W = Up / going Forward
A = Left
D = Right
S = Down / going Backward

Hold Shift = Run
E = Opening Door / Examine

Esc = Open Menu
Enter = Yes
Shift = No / Back

Z = Previous Tab
X = Next Tab
Alt = Pause
F1 = Replaying the Monokuman Map

C = Switch to Genocide Jack / Back to Komaru
F = Choosing Truth Bullets
R = Rotate to Camera to face which ever direction the character is facing

Number 1~8 can be used for shortcut of using truth bullets
1 = Break Bullets
2 = Knock Back
3 = Dance
4 = Paralyze
5 = Move Bullets
6 = Burn
7 = Detect
8 = Link

You can also use Directional Arrow to choose 4 general kinds of truth bullets

Left-Click = Attack / Yes
Right-Click = Ready to Attack / No / Back [in Menu]
Scroll-Wheel = Changing Truth bullets

Left-Click = Attack
Shift = Evade
Hold Left-Click = Special Skill
Right-Click = Focusing on Enemy
Space / Ctrl = Slash Lust

Right-Click + Space = One Combo Attack
Right-Click + Ctrl = Three Combo Attack

Esc = Skip Event Completely
Hold Shift = Fast Forward Dialogues
X = Auto Dialogues
F1 = Hide Dialogues
C / Mouse 3 = See Transcript while Dialogues are still going
[which can also be read later in System Section from the Menu; use E = Replay the Voice]

Special Thanks for @Potato_薯 , @Vain and @ Masaki Ren @wiineko for helping me found all of these Information ..